This second article, in a series of two, on the physiological approach of psychiatric semiology proposes to explore the place of physiology and clinical semiology according to a systemic biology approach. While the approach of psychiatric semiology has been closely linked to the construction of contemporary classifications of psychiatric disorders, two approaches tending to break away from classical nosographies have been proposed the psychosystems project and the Cambridge model. For each of these approaches will be presented the general principle, the link with physiology and semiology, and the main limitations. It will be proposed to include the psychosystems project as well as the Cambridge model from a systemic biology perspective that could reintegrate semiology as an essential level of the psychiatric disorder approach, between biological and social value. The issues of such biological and social constraints will be approached according to an epistemological approach, notably through the questions raised by neurophenomenology, in order to propose a perspective of clinical neurophysiology to psychiatry that is to say of a neurophysiology that takes seriously the clinical knowledge historically constituted of psychiatry, but also a clinic that does not deny the advances in neurophysiology on the understanding of brain function.